Sickle Cell Anemia

HBB: The Gene Associated with Sickle Cell Anemia


Approximate gene fixing is based on Chromosome 11 map from NCBI Entrez Map Viewer.
authoritative Gene Symbol: HBB

Name of Gene Product: hemo hematohiston, of import

Alternate Name of Gene Product: important globin

venue: 11p15.5 - The HBB gene is base in region 15.5 on the con (p) arm of human chromosome 11.

Gene Structure: The normal allelomorphic variant for this gene is 1600 base pairs (bp) long and contains three exons.

template RNA: The intron-free mRNA transcript for the HBB gene is 626 base pairs long. See the NCBI eon record NM_000518 to access the mRNA sequence data.

Coding era (CDS): 444 base pairs within the mRNA code for the amino caustic sequence of the genes protein product.

Protein Size: The HBB protein is 146 amino acids long and has a molecular(a) weight of 15,867 Da. See the annotated HBB protein sequence record in Swiss-Prot.

Protein belong: Hemoglobin shreds, which reside in red blood cellph unmatchables, atomic number 18 responsible for carrying oxygen from the lungs to various parts of the body for mapping in respiration. The HBB gene codes for one of the two types of polypeptide chains found in adult hemoglobin. Normal adult hemoglobin is a tetrameric protein consisting of two alpha chains and two of import chains.



HBB codes for the beta chain, which is often referred to as beta globin. Mutant beta globin is responsible for the sickling of red blood cells seen in sickle cell anemia.

Protein Structure

The structure of normal deoxy hemoglobin is shown in ascertain 1. The four gray clusters ar noncovalently bonded hematin groups. Each heme serves as a contact site for binding one molecule of oxygen. The two gold spheres near the top of the molecule are phosphate groups. The green and blue chains are alpha chains, and the gold and aqua chains are beta chains. The red box highlights the general region of two beta chains where the sixth glutamic acid residue is located. A inheritable variant associated with this amino acid...If you want to get a all-inclusive essay, order it on our website: Orderessay



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