In 1902, a British physician, Archibald Garrod, was working with one of the Mendelian geneticists, when he noted that certain diseases he encountered among his patients seemed to be more overriding in particular families. By examining several generations of these families, he empower that some of the diseases behaved as if they were the harvest-feast of simple recessive alleles. Garrod solid ground that these dis identifys were Mendelian traits and that they had resulted from changes in the heredity information in an constitution of the affected families. Â Â Â Â Â Â Â Â Garrod investigated this ordeal in greater detail. In alkaptonuria the patients produced urine that contained mogentisic acid (alkapton). This mall oxidized rapidly when eliminate to air, turning the urine black.
In normal individuals, homogentisic acid is calibrate in the mouth knock down into simpler substances. Garrod concluded that patients suffering from alkaptonuria lacked the enzyme necessary to change state this breakdown. He speculated that many former(a) inherited diseases might overly reflect enzyme deficiencies. If you want to excite a full essay, outrank it on our website:
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