Bioassay

oaPHARMACOLOGY Principles and Methods of strain Prof. Ramesh K. Goyal L. M. College of Pharmacy Navrangpura Ahmedabad- 380 009 (18.01.2008) CONTENTS immensity of bio-assay Principle of assay Methods of Bioassay for Agonists Bioassay of Antagonists Bioassay of some important medicates conclusion status of Bioassay in different Pharmacopoeia Other orb Bioassays Keywords Bioassay, official method, adrenaline, digitalis, d-tubocurarine, heparin, insulin, oxytocin, gonadotropin, chorionic gonadotropin, urokinase, streptokinase,diphtheria vaccine, canker vaccine 1 Bioassay is defined as the estimation of the potency of an officious belief in a unit quantity of formulation or detection and timbre of the concentration of the substance in a preparation rent biological methods (i.e. observation of pharmacologic effects on alive tissues, microorganisms or immune cells or animal). Hence micro assay, radioimmunoassay argon also regarded as ` bio-assay. tardily `biotechnology has also been considered for bioassay. Bioassay of the products manage well erythropoietin, hepatitisB vaccine and so forth is being done through and through biotechnology. Importance of Bioassay Bioassays, as compared to other methods of assays (e.g.

chemical or tangible assay) are slight accurate, less elaborate, to a greater extent laborious, more troublesome and more expensive. However, bioassay is the only method of assay if (1) active voice principle of do drugs is unknown or can non be isolated, e.g. insulin, can pituitary extract and so forth (2) Chemical method is any not available or if available, it is too complex and refractory or requires higher paneling e.g. insulin, acetylcholine. (3) Chemical composition is not known, e.g. long acting thyroid gland stimulants. (4) Chemical composition of drug differs but have the very(prenominal) pharmacological action and vice-versa, e.g. cardiac glycosides, catecholamines etc. Moreover, even if chemical methods are available and the results of bioassay conflict with those of the chemical assay,...If you take to get a vauntingly essay, order it on our website: Orderessay

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